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Anti-TRPM8 Antibody EPR4196(2)
Also for TRPM8 (NM_024080)
|A synthetic peptide corresponding to residues in the extracellular domain in human TRPM8 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1:250 - 1:500; WB: 1:1000 - 1:10000
|Does not react with Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens transient receptor potential cation channel, subfamily M, member 8 (TRPM8)|
|TRPM8, or Transient receptor potential cation channel subfamily M member 8, is a receptor-activated non-selective cation channel involved in the detection of sensations such as coolness, by being activated by cold temperatures below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Activated upon depolarization, changes in temperature result in graded shifts of voltage-dependent activation curves for TRPM8. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. TRPM8 is expressed in the prostate, and it is also expressed in most prostate tumors (1).|
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Western blot - TRPM8 antibody [EPR4196(2)]; All lanes : Anti-TRPM8 antibody [EPR4196(2)] at 1/1000 dilution.Lane 1 : HT-1376 cell lysates .Lane 2 : LnCaP cell lysates .Lane 3 : A549 cell lysates .Lysates/proteins at 10 µg per lane.Predicted band size : 128 kDa.Observed band size : 130 kDa .