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Home Antibody All anti-TRPM8 antibodies

Anti-TRPM8 Antibody EPR4196(2)


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against TRPM8(clone EPR4196(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402977) , 20ug Explanation
100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain in human TRPM8 was used as an immunogen.
Clone NameEPR4196(2) IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsICC: 1:250 - 1:500; WB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens transient receptor potential cation channel, subfamily M, member 8 (TRPM8)
Alternative NameLTRPC6; TRPP8
Database LinkNP_076985
Entrez Gene 79054 Human
Entrez Gene 171382 Mouse
FunctionTRPM8, or Transient receptor potential cation channel subfamily M member 8, is a receptor-activated non-selective cation channel involved in the detection of sensations such as coolness, by being activated by cold temperatures below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Activated upon depolarization, changes in temperature result in graded shifts of voltage-dependent activation curves for TRPM8. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. TRPM8 is expressed in the prostate, and it is also expressed in most prostate tumors (1).
Related PathwayIon Channels: Transient receptor potentialTransmembraneDruggable Genome

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - TRPM8 antibody [EPR4196(2)]; All lanes : Anti-TRPM8 antibody [EPR4196(2)] at 1/1000 dilution.Lane 1 : HT-1376 cell lysates .Lane 2 : LnCaP cell lysates .Lane 3 : A549 cell lysates .Lysates/proteins at 10 ug per lane.Predicted band size : 128 kDa.Observed band size : 130 kDa .


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