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Anti-AXIN2 Antibody EPR2005(2)
Also for AXIN2 (NM_004655)
|A synthetic peptide corresponding to residues in human Axin-2 was used as an immunogen.|
|Mouse, Rat, Human, Pig
||Lot dependent; please refer to CoA along with shipment
||ICC/IF: 1:100; WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens axin 2 (AXIN2)|
Entrez Gene 8313 Human
Entrez Gene 12006 Mouse
Entrez Gene 29134 Rat
|The Axin-related protein, Axin-2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. Axin-2 has been linked to a frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in Axin-2 have been associated with colorectal cancer with defective mismatch repair.|
|ES Cell Differentiation/IPSInduced pluripotent stem cellsDruggable Genome Wnt signaling pathwayPathways in cancerColorectal cancerEndometrial cancerBasal cell carcinoma|
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Western blot - Axin 2 antibody [EPR2005(2)]; All lanes : Anti-Axin 2 antibody [EPR2005(2)] at 1/1000 dilution.Lane 1 : MCF7 cell lysates .Lane 2 : SW480 cell lysates .Lane 3 : PC3 cell lysates .Lysates/proteins at 10 ug per lane.Predicted band size : 94 kDa.Observed band size : 95 kDa .