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Anti-RET Antibody EPR2871
|A synthetic peptide corresponding to residues on the C-terminus of human Ret was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, FC
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; FC: 1:100 - 1:1000; ICC/IF: 1:50 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Homo sapiens ret proto-oncogene (RET), transcript variant 4|
|CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51|
Entrez Gene 5979 Human
Entrez Gene 19713 Mouse
Entrez Gene 24716 Rat
|Ret, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. It plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in Ret are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.|
|Protein KinaseTransmembraneDruggable Genome EndocytosisPathways in cancerThyroid cancer|
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Western blot - Anti-Ret antibody [EPR2871]; All lanes : Anti-Ret antibody [EPR2871] at 1/10000 dilution.Lane 1 : Neuro-2a cell lysate.Lane 2 : TT cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 124 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ret antibody [EPR2871]; Immunohistochemical analysis of paraffin-embedded Human thyroid gland carcinoma tissue labelling Ret with TA307815 at 1/250 dilution.
Flow Cytometry - Anti-Ret antibody; Overlay histogram showing Caco 2 cells stained with TA307815 (red line). The secondary antibody used was Alexa Fluor 488 goat anti-rabbit IgG (H&L) at 1:2000. Isotype control antibody (black line) was rabbit IgG (monoclonal) used under the same conditions. Unlabelled sample (blue line) was also used as a control.