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Home Antibody All anti-ORAI1 antibodies

Anti-ORAI1 Antibody EPR3394(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307810
  • Rabbit monoclonal antibody against Orai1(clone EPR3394(2))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403208) , 20ug
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Orai1 was used as an immunogen.
Clone NameEPR3394(2) IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-Fr,IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC,IHC-Fr,IHC-P or IP.

Reference Data

Target NameHomo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)
Alternative NameCRACM1; IMD9; ORAT1; TMEM142A
Database LinkNP_116179
FunctionOrai1 is a Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Defects in Orai1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) (1).
Related Pathway

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WB Image
Western blot - Orai1 antibody [EPR3394(2)]; All lanes : Anti-Orai1 antibody [EPR3394(2)] at 1/1000 dilution.Lane 1 : Human platelet lysate.Lane 2 : Human ovary cancer lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 33 kDa.

 

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