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Anti-ORAI1 Antibody EPR3394(2)
Also for ORAI1 (NM_032790)
|A synthetic peptide corresponding to residues in human Orai1 was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,ICC,IHC-Fr,IHC-P or IP.
|Homo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)|
|CRACM1; IMD9; ORAT1; TAM2; TMEM142A|
Entrez Gene 84876 Human
|Orai1 is a Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Defects in Orai1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) (1).|
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Western blot - Orai1 antibody [EPR3394(2)]; All lanes : Anti-Orai1 antibody [EPR3394(2)] at 1/1000 dilution.Lane 1 : Human platelet lysate.Lane 2 : Human ovary cancer lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 33 kDa.