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Anti-LRP6 Antibody EPR2423(2)


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against LRP6(clone EPR2423(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419396) , 20ug Explanation
100ul $325 3 Weeks
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human LRP6 was used as an immunogen.
Clone NameEPR2423(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 180 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens low density lipoprotein receptor-related protein 6 (LRP6)
Alternative NameADCAD2
Database LinkNP_002327
Entrez Gene 4040 Human
Entrez Gene 16974 Mouse
Entrez Gene 312781 Rat
FunctionLRP6 (low-density lipoprotein receptor-related protein 6) is a single span transmembrane Wnt receptor that interacts with Axin to promote the Wnt-dependent accumulation of beta-catenin. Cells treated with Wnt quickly induce plasma membrane-associated LRP6 aggregates. The aggregates are phosphorylated, and then promote Axin recruitment and beta-catenin stabilization. LRP6 is internalized with caveolin and components of this endocytic pathway are required not only for Wnt-3a-induced internalization of LRP6 but also for accumulation of beta-catenin (1-2).
Related PathwayTransmembraneDruggable Genome Wnt signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-LRP6 antibody [EPR2423(2)]; All lanes : Anti-LRP6 antibody [EPR2423(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysates .Lane 2 : HepG2 cell lysates .Lane 3 : 293T cell lysates .Lane 4 : Jurkat cell lysates .Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 180 kDa.
Immunocytochemistry/ Immunofluorescence - Anti-LRP6 antibody [EPR2423(2)]; Immunofluorescence analysis of HeLa cells labelled with TA307797 at 1/100 dilution.


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