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Anti-LRP6 Antibody EPR2423(2)
Also for LRP6 (NM_002336)
|A synthetic peptide corresponding to residues in human LRP6 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6)|
Entrez Gene 4040 Human
Entrez Gene 16974 Mouse
Entrez Gene 312781 Rat
|LRP6 (low-density lipoprotein receptor-related protein 6) is a single span transmembrane Wnt receptor that interacts with Axin to promote the Wnt-dependent accumulation of beta-catenin. Cells treated with Wnt quickly induce plasma membrane-associated LRP6 aggregates. The aggregates are phosphorylated, and then promote Axin recruitment and beta-catenin stabilization. LRP6 is internalized with caveolin and components of this endocytic pathway are required not only for Wnt-3a-induced internalization of LRP6 but also for accumulation of beta-catenin (1-2).|
|TransmembraneDruggable Genome Wnt signaling pathway|
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Western blot - Anti-LRP6 antibody [EPR2423(2)]; All lanes : Anti-LRP6 antibody [EPR2423(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysates .Lane 2 : HepG2 cell lysates .Lane 3 : 293T cell lysates .Lane 4 : Jurkat cell lysates .Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 180 kDa.
Immunocytochemistry/ Immunofluorescence - Anti-LRP6 antibody [EPR2423(2)]; Immunofluorescence analysis of HeLa cells labelled with TA307797 at 1/100 dilution.