Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6)
Synonyms:
ADCAD2
Immunogen
A synthetic peptide corresponding to residues in human LRP6 was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
LRP6 (low-density lipoprotein receptor-related protein 6) is a single span transmembrane Wnt receptor that interacts with Axin to promote the Wnt-dependent accumulation of beta-catenin. Cells treated with Wnt quickly induce plasma membrane-associated LRP6 aggregates. The aggregates are phosphorylated, and then promote Axin recruitment and beta-catenin stabilization. LRP6 is internalized with caveolin and components of this endocytic pathway are required not only for Wnt-3a-induced internalization of LRP6 but also for accumulation of beta-catenin (1-2).
Related Pathway
Wnt Signaling Pathway
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