Home All anti-FEN1 antibodies
Anti-FEN1 Antibody EPR4459(2)
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for FEN1 (NM_004111)
|A synthetic peptide corresponding to residues in human FEN1 was used as an immunogen.|
|Human, Mouse, Rat
||IHC: 1:500 - 1,000, WB: 1:1,000 - 10,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens flap structure-specific endonuclease 1 (FEN1)|
|FEN-1; MF1; RAD2|
|FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. FEN1 is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by FEN1. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions (1).|
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis on (A) Jurkat and (B) HeLa cell lysates using anti-FEN1 RabMAb .
Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-FEN1 RabMAb .