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Anti-EPOR PHOSPHO Antibody EPR2266
Also for EPOR (NM_000121)
|A phospho specific peptide corresponding to residues surrounding Tyrosine 485 of human EpoR was used as an immunogen. The antibody only detects EpoR phosphorylated at Tyrosine 485.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens erythropoietin receptor (EPOR), transcript variant 1|
Entrez Gene 2057 Human
|Erythropoietin (Epo) is a hematopoietic cytokine that is a potent regulator of the viability, differentiation and proliferation of erythroid progenitor cells (1, 3). Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins (1). EpoR shares conserved features in its extracellular and cytoplasmic domains with other family members of cytokine and growth factor receptors (2). Alterations of the Epo/EpoR system have recently been shown to be involved in the pathogenesis of familial erythrocytosis and polycythaemia vera (PV) (3). |
|Secreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathwayHematopoietic cell lineage|
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Western blot - EPO Receptor (phospho Y485) antibody [EPR2266]; All lanes : Anti-EPO Receptor (phospho Y485) antibody [EPR2266] at 1/50000 dilution.Lane 1 : MCF-7 cell lysate untreated.Lane 2 : MCF-7 cell lysate treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugate at 1/2000 dilution.Predicted band size : 55 kDa.Observed band size : 59 kDa .