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Home Antibody All anti-EPOR antibodies

Anti-EPOR PHOSPHO Antibody EPR2266

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307751
  • Rabbit monoclonal antibody against EpoR Phospho (pY485) (clone EPR2266 ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 485 of human EpoR was used as an immunogen. The antibody only detects EpoR phosphorylated at Tyrosine 485.
Clone NameEPR2266 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:20
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens erythropoietin receptor (EPOR), transcript variant 1
Alternative NameEPO-R
Database LinkNP_000112
FunctionErythropoietin (Epo) is a hematopoietic cytokine that is a potent regulator of the viability, differentiation and proliferation of erythroid progenitor cells (1, 3). Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins (1). EpoR shares conserved features in its extracellular and cytoplasmic domains with other family members of cytokine and growth factor receptors (2). Alterations of the Epo/EpoR system have recently been shown to be involved in the pathogenesis of familial erythrocytosis and polycythaemia vera (PV) (3).
Related Pathway
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Jak-STAT signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - EPO Receptor (phospho Y485) antibody [EPR2266]; All lanes : Anti-EPO Receptor (phospho Y485) antibody [EPR2266] at 1/50000 dilution.Lane 1 : MCF-7 cell lysate untreated.Lane 2 : MCF-7 cell lysate treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugate at 1/2000 dilution.Predicted band size : 55 kDa.Observed band size : 59 kDa .

 

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