Erythropoietin (Epo) is a hematopoietic cytokine that is a potent regulator of the viability, differentiation and proliferation of erythroid progenitor cells (1, 3). Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins (1). EpoR shares conserved features in its extracellular and cytoplasmic domains with other family members of cytokine and growth factor receptors (2). Alterations of the Epo/EpoR system have recently been shown to be involved in the pathogenesis of familial erythrocytosis and polycythaemia vera (PV) (3).
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Jak-STAT signaling pathway
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