Estrogen receptor alpha (ER alpha) is a ligand-activated transcription factor and member of the steroid hormone receptor family. It possesses highly conserved DNA binding and ligand binding domains for hormone binding, exerting a significant role in activating the transcription of certain genes (1). ER alpha binds to estrogen response elements (ERE) to regulate estrogen-responsive gene expression (2). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (3). Phosphorylation of serines 104 and 106, located in the N-terminal transcription activation function-1 domain (AF-1), regulates ER alpha activity (4). It is a prognostic marker for breast cancer because ER alpha is present in the mammary gland (5).
TGF Beta Signaling Pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.