Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1
Synonyms:
ER; Era; ESR; ESRA; NR3A1
Immunogen
A recombinant human ER alpha protein was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Estrogen receptor alpha (ER alpha) is a ligand-activated transcription factor and member of the steroid hormone receptor family. It possesses highly conserved DNA binding and ligand binding domains for hormone binding, exerting a significant role in activating the transcription of certain genes (1). ER alpha binds to estrogen response elements (ERE) to regulate estrogen-responsive gene expression (2). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (3). Phosphorylation of serines 104 and 106, located in the N-terminal transcription activation function-1 domain (AF-1), regulates ER alpha activity (4). It is a prognostic marker for breast cancer because ER alpha is present in the mammary gland (5).
Related Pathway
TGF Beta Signaling Pathway
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