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Home Antibody All anti-F13A1 antibodies

Anti-F13A1 Antibody EP3371


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307747 Rabbit monoclonal antibody against Factor XIII A (clone EP3371 ) 100ul $325 In Stock
LC400044 F13A1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Factor XIII A was used as an immunogen.
Clone NameEP3371 IsotypeIgG
Species ReactivityRat, Human (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens coagulation factor XIII A chain (F13A1)
Alternative NameF13A
Database LinkNP_000120
Entrez Gene 2162 Human
Entrez Gene 60327 Rat
FunctionFactor XIII (plasma transglutaminase, fibrin stabilizing factor) is a plasma protein that plays an important role in the final stages of blood coagulation and fibrinolysis. It circulates in blood as a tetramer consisting of two “A” and two “B” subunits (1, 2). The amino acid sequence of the enzymatically active subunit, Factor XIII A, is unique and does not exhibit internal homology, but its active center is similar to that of the thiol proteases. Factor XIII A is activated by thrombin and calcium ion to a transglutaminase that catalyzes the cross linking of fibrin molecules, forming intermolecular isopeptide bonds, thus stabilizing blood clots (3, 4). In two diseases that share some histological resemblance (Lymphocyte-poor graft-versus-host-reaction and toxic epidermal necrolysis), Factor-XIII A-positive dendrocytes show some morphological changes, probably as a response to altered cytokine environment. Factor-XIII A-positive dendrocytes thus are reported to possibly play a role in the regulation of the connective tissue remodeling that may accompany epidermal destruction (5).
Related PathwaySecreted ProteinDruggable Genome Complement and coagulation cascades

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Factor XIIIa antibody [EP3371]; All lanes : Anti-Factor XIIIa antibody [EP3371] at 1/2000 dilution.Lane 1 : Human placenta lysate.Lane 2 : PMBC lysate.Lane 3 : Rat platelets lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 83 kDa.Observed band size : 83 kDa.Additional bands at : 65 kDa,75 kDa. We are unsure as to the identity of these extra bands.


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