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Anti-F13A1 Antibody EP3371
Also for F13A1 (NM_000129)
|A synthetic peptide corresponding to residues in human Factor XIII A was used as an immunogen.|
|Rat, Human (Does not react with: Mouse)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:2000; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for IHC-P.
|Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1)|
Entrez Gene 2162 Human
Entrez Gene 60327 Rat
|Factor XIII (plasma transglutaminase, fibrin stabilizing factor) is a plasma protein that plays an important role in the final stages of blood coagulation and fibrinolysis. It circulates in blood as a tetramer consisting of two “A” and two “B” subunits (1, 2). The amino acid sequence of the enzymatically active subunit, Factor XIII A, is unique and does not exhibit internal homology, but its active center is similar to that of the thiol proteases. Factor XIII A is activated by thrombin and calcium ion to a transglutaminase that catalyzes the cross linking of fibrin molecules, forming intermolecular isopeptide bonds, thus stabilizing blood clots (3, 4). In two diseases that share some histological resemblance (Lymphocyte-poor graft-versus-host-reaction and toxic epidermal necrolysis), Factor-XIII A-positive dendrocytes show some morphological changes, probably as a response to altered cytokine environment. Factor-XIII A-positive dendrocytes thus are reported to possibly play a role in the regulation of the connective tissue remodeling that may accompany epidermal destruction (5). |
|Secreted ProteinDruggable Genome Complement and coagulation cascades|
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Western blot - Factor XIIIa antibody [EP3371]; All lanes : Anti-Factor XIIIa antibody [EP3371] at 1/2000 dilution.Lane 1 : Human placenta lysate.Lane 2 : PMBC lysate.Lane 3 : Rat platelets lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 83 kDa.Observed band size : 83 kDa.Additional bands at : 65 kDa,75 kDa. We are unsure as to the identity of these extra bands.