A synthetic peptide corresponding to residues in human Integrin beta-3 (CD61 antigen) was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Integrin beta-3 (CD61 antigen, GP IIIa) is a member of the integrin family of integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins (1). Integrin beta-3 forms a Ca2+-dependent heterodimer complex with the GP IIb chain in platelets (2). The cytoplasmic domain of Integrin beta-3 has be suggested to have a key role in cell adhesion (3). Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces (4).
Related Pathway
Focal Adhesion
Hematopoietic cell lineage
Hemostasis
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis on (A) THP-1 treated with TPA, (B) HUVEC, (C) human spleen and (D) human plasma lysates using anti-Integrin beta-3 (CD61 antigen) RabMAb .
Researchers who bought this antibody have also purchased:
