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Anti-ITGB3 Antibody EPR2342


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Integrin beta-3 (CD61 antigen) (clone EPR2342 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424861) , 20ug Explanation
100ul $325 3-7 Days
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Also for ITGB3 (NM_000212)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Integrin beta-3 (CD61 antigen) was used as an immunogen.
Clone NameEPR2342 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000; IP: 1:50
Predicted MW Explanation 87 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Whole antiserum
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3)
Alternative NameBDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT
Database LinkNP_000203
Entrez Gene 3690 Human
Entrez Gene 16416 Mouse
Entrez Gene 29302 Rat
FunctionIntegrin beta-3 (CD61 antigen, GP IIIa) is a member of the integrin family of integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins (1). Integrin beta-3 forms a Ca2+-dependent heterodimer complex with the GP IIb chain in platelets (2). The cytoplasmic domain of Integrin beta-3 has be suggested to have a key role in cell adhesion (3). Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces (4).
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Focal adhesionECM-receptor interactionHematopoietic cell lineageRegulation of actin cytoskeletonHypertrophic cardiomyopathy (HCM)Arrhythmogenic right ventricular cardiomyopathy (ARVC)More Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-Integrin beta 3 antibody [EPR2342]; All lanes : Anti-Integrin beta 3 antibody [EPR2342] at 1/1000 dilution.Lane 1 : TPA treated THP1 cell lysate.Lane 2 : HUVEC cell lysate.Lane 3 : Human spleen lysate.Lane 4 : Human plasma lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 87 kDa.Observed band size : 110 kDa .


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