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Home Antibody All anti-MSH2 antibodies

Anti-MSH2 Antibody EPR3944

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307732
  • Rabbit monoclonal antibody against MSH2(clone EPR3944)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424843) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for MSH2 (NM_000251)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MSH2 was used as an immunogen.
Clone NameEPR3944 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IHC-P.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens mutS homolog 2 (MSH2), transcript variant 1
Alternative NameCOCA1; FCC1; HNPCC; HNPCC1; LCFS2
Database LinkNP_000242
FunctionMutS homologue 2 (MSH2) is a DNA mismatch repair protein in the MutS family (1). MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3) that bind to DNA mismatches thereby initiating DNA repair. (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA (2). MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long (2). Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6 (3, 4). MSH2 is the most frequently detected mutation among MutS family proteins in HNPCC (1). MutS alpha may also play a role in DNA homologous recombination repair (2).
Related Pathway

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WB Image
Western blot - Anti-MSH2 antibody [EPR3944]; All lanes : Anti-MSH2 antibody [EPR3944] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : A375 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 105 kDa.

 

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