OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-MSH2 antibodies

Anti-MSH2 Antibody EPR3944

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307732
  • Rabbit monoclonal antibody against MSH2(clone EPR3944)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424843) , 20ug Explanation
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
spacer
Also for MSH2 (NM_000251)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MSH2 was used as an immunogen.
Clone NameEPR3944 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IHC-P.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens mutS homolog 2 (MSH2), transcript variant 1
Alternative NameCOCA1; FCC1; HNPCC; HNPCC1; LCFS2
Database LinkNP_000242
Entrez Gene 4436 Human
FunctionMutS homologue 2 (MSH2) is a DNA mismatch repair protein in the MutS family (1). MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3) that bind to DNA mismatches thereby initiating DNA repair. (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA (2). MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long (2). Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6 (3, 4). MSH2 is the most frequently detected mutation among MutS family proteins in HNPCC (1). MutS alpha may also play a role in DNA homologous recombination repair (2).
Related PathwayStem cell - PluripotencyDruggable Genome Mismatch repairPathways in cancerColorectal cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-MSH2 antibody [EPR3944]; All lanes : Anti-MSH2 antibody [EPR3944] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : A375 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 105 kDa.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title