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Anti-MSH2 Antibody EPR3944
Also for MSH2 (NM_000251)
|A synthetic peptide corresponding to residues in human MSH2 was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IHC-P.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens mutS homolog 2 (MSH2), transcript variant 1|
|COCA1; FCC1; HNPCC; HNPCC1; LCFS2|
Entrez Gene 4436 Human
|MutS homologue 2 (MSH2) is a DNA mismatch repair protein in the MutS family (1). MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3) that bind to DNA mismatches thereby initiating DNA repair. (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA (2). MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long (2). Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6 (3, 4). MSH2 is the most frequently detected mutation among MutS family proteins in HNPCC (1). MutS alpha may also play a role in DNA homologous recombination repair (2).|
|Stem cell - PluripotencyDruggable Genome Mismatch repairPathways in cancerColorectal cancer|
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Western blot - Anti-MSH2 antibody [EPR3944]; All lanes : Anti-MSH2 antibody [EPR3944] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : A375 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 105 kDa.