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Anti-NF2 Antibody EPR2573(2)
|A synthetic peptide corresponding to the C-terminus of human Merlin was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50000 - 1:200000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 1|
|ACN; BANF; SCH|
|Merlin is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. It has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Merlin is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in Merlin are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities (1).|
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Western blot - NF2 / Merlin antibody [EPR2573(2)]; All lanes : Anti-NF2 / Merlin antibody [EPR2573(2)] at 1/50000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : PC3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 70 kDa.