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Anti-PTS PHOSPHO Antibody EPR1517(2)
|A phospho specific peptide corresponding to residues surrounding Serine 19 of human PTP Synthase was used as an immunogen. This antibody only detects PTP Synthase phosphorylated at Serine 19.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC/IF: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt.
|Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS)|
Entrez Gene 5805 Human
|PTP Synthase catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in PTP Synthase result in hyperphenylalaninemia (1). Phosphorylation of Serine 19 is required for maximal enzyme activity (2).|
|Druggable Genome Folate biosynthesisMetabolic pathways|
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Western blot - PTS (phospho S19) antibody [EPR1517(2)]; All lanes : Anti-PTS (phospho S19) antibody [EPR1517(2)] at 1/1000 dilution.Lane 1 : HUVEC cell lysates .Lane 2 : HUVEC cell lysates treated with Alkaline Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 16 kDa.Observed band size : 17 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PTS (phospho S19) antibody [EPR1517(2)]; TA307723, at a 1/250 dilution, staining PTS (phospho S19) in paraffin embedded Human brain tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - PTS (phospho S19) antibody [EPR1517(2)]; TA307723, at a 1/250 dilution, staining PTS (phospho S19) in HeLa cells by Immunofluorescence.