Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS)
Synonyms:
PTPS
Immunogen
A phospho specific peptide corresponding to residues surrounding Serine 19 of human PTP Synthase was used as an immunogen. This antibody only detects PTP Synthase phosphorylated at Serine 19.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
PTP Synthase catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in PTP Synthase result in hyperphenylalaninemia (1). Phosphorylation of Serine 19 is required for maximal enzyme activity (2).
Related Pathway
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