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Anti-RB1 Phospho Antibody EPR224
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|A phospho specific peptide corresponding to residues surrounding Serine 811 of human Rb was used as an immunogen. This antibody only detects Rb phosphorylated at Serine 811.|
|Human, Mouse, Rat
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens retinoblastoma 1 (RB1)|
|OSRC; p105-Rb; pp110; pRb; RB|
|Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdks inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).|
Senescence and Autophagy
TGF Beta Signaling Pathway
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Western blot analysis on Jurkat cell lysates using anti-Phospho-Rb (pS811) RabMAb .