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Anti-RB1 PHOSPHO Antibody EPR224
|A phospho specific peptide corresponding to residues surrounding Serine 811 of human Rb was used as an immunogen. This antibody only detects Rb phosphorylated at Serine 811.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ICC/IF: Use at an assay dependent concentration; WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens retinoblastoma 1 (RB1)|
|OSRC; p105-Rb; pp110; pRb; RB|
|Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdks inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).|
Senescence and Autophagy
TGF Beta Signaling Pathway
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Western blot - Anti-Rb (phospho S811) antibody [EPR224]; All lanes : Anti-Rb (phospho S811) antibody [EPR224] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Jurkat cell lysate treated with FBS.Lysates/proteins at 10 µg per lane.Predicted band size : 106 kDa.