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Home Antibody All anti-RB1 antibodies

Anti-RB1 Antibody EP44(2)


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307721 Rabbit monoclonal antibody against Rb (clone EP44(2) ) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Rb was used as an immunogen.
Clone NameEP44(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens retinoblastoma 1 (RB1)
Alternative NameOSRC; p105-Rb; pp110; pRb; RB
Database LinkNP_000312
Entrez Gene 5925 Human
FunctionRetinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1, 2). Cell cycle-dependent phosphorylation by cdk's inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).
Related PathwayTranscription FactorsDruggable Genome Cell cyclePathways in cancerPancreatic cancerGliomaProstate cancerMelanomaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Rb antibody [EP44(2)]; All lanes : Anti-Rb antibody [EP44(2)] at 1/1000 dilution.Lane 1 : Jurkat cell lysates.Lane 2 : K562 cell lysates.Lysates/proteins at 10 ug per lane.Predicted band size : 106 kDa.


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