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Anti-HSD17B1 Antibody EP1681Y
Also for HSD17B1 (NM_000413)
|A synthetic peptide corresponding to residues on the C-terminus of human HSD17B1 was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:2000; IHC-P: 1:100 - 1:250; FC: 1:40; ICC/IF: 1:50
|Does not react with Mouse, Rat. Is unsuitable for IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for IP.
|Homo sapiens hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1)|
|EDH17B2; EDHB17; HSD17; SDR28C1|
Entrez Gene 3292 Human
|The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4) |
|Druggable Genome Androgen and estrogen metabolismMetabolic pathways|
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Western blot - Anti-HSD17B1 antibody [EP1681Y]; Anti-HSD17B1 antibody [EP1681Y] at 1/500 dilution + Human placenta lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 35 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSD17B1 antibody [EP1681Y]; Immunohistochemical analysis of paraffin-embedded Human placenta tissue labelling HSD17B1 with TA307711 at 1/100 dilution.