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Anti-SOD1 Antibody EPR1726
Also for SOD1 (NM_000454)
|A synthetic peptide corresponding to residues in human SOD1 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||ICC/IF: 1:200; WB: 1:100000 - 1:200000; IP: 1:10; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt.
|Homo sapiens superoxide dismutase 1, soluble (SOD1)|
|ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD|
Entrez Gene 6647 Human
|Cu/Zn superoxide dismutase (SOD1), a major intracellular antioxidant enzyme, metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide (1). SOD1 is primarily a cytosolic protein, and is ubiquitously expressed in many tissues at higher levels than in the brain and spinal cord (1, 2). The structural interplay of the conserved disulfide bond and metal-site occupancy in SOD1 is of increasing interest as these post-translational modifications are known to dramatically alter the catalytic chemistry, the subcellular localization, and the susceptibility of the protein to aggregation (3). Defective SOD is linked to motor neuron death and carries implications for understanding and possible treatment of the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS) (4). |
|Druggable Genome Amyotrophic lateral sclerosis (ALS)Huntington's diseasePrion diseases|
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Western blot - Superoxide Dismutase 1 antibody [EPR1726]; All lanes : Anti-Superoxide Dismutase 1 antibody [EPR1726] at 1/200000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : HT29 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 16 kDa.Observed band size : 16 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Superoxide Dismutase 1 antibody [EPR1726]; TA307705 at 1/250 dilution staining Superoxide Dismutase 1 in human kidney by Immunohistochemistry, Paraffin-embedded tissue.
Immunocytochemistry/ Immunofluorescence - Superoxide Dismutase 1 antibody [EPR1726]; TA307705 (1/200) staining Superoxide Dismutase 1 in assynchronous HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.5% Triton X-100 and counterstained with DAPI in order to highlight the nucleus.