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Anti-FGA Antibody EPR2919
|A synthetic peptide corresponding to residues in human Fibrinogen (alpha chain) was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1:50 - 100, IHC: 1:50 - 100, IP: 1:50, WB: 1:2,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse
|Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E|
|Fibrinogen is a plasma glycoprotein synthesized primarily in the liver (1). It is comprised of two identical molecular halves, each consisting of three non-identical subunit polypeptides designated as A alpha, B beta- and gamma-chains held together by multiple disulfide bonds (2). Fibrinogen acts as the main factor in the formation of a blood clot by polymerization to a fibrin network and by enabling platelets to aggregate (3). The conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Defects in fibrinogen are a cause of congenital afibrinogenemia, a rare autosomal recessive disorder, and amyloidosis type 8, also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis (4). |
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Western blot - Fibrinopeptide A antibody [EPR2919]; All lanes : Anti-Fibrinopeptide A antibody [EPR2919] at 1/2000 dilution.Lane 1 : Human plasma lysate.Lane 2 : Fetal liver lysate.Lane 3 : HepG2 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 95 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Fibrinopeptide A antibody [EPR2919]; Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using ab92572 at 1/2000 dilution.