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Home Antibody All anti-FGG antibodies

Anti-FGG Antibody EPR3084

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307696
  • Rabbit monoclonal antibody against Fibrinogen gamma chain (clone EPR3084 )
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400173) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for FGG (NM_000509)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Fibrinogen gamma chain was used as an immunogen.
Clone NameEPR3084 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsIHC: 1:100 - 250, WB: 1:500 - 1,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A
Alternative Namefibrinogen, gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain
Database LinkNP_000500
FunctionFibrinogen is comprised of two sets of three polypeptide chains termed alpha, beta and gamma that are joined by disulfide bridging within the N-terminal E domain (1). Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen binds through its gamma chain to cell surface receptors, growth factors, and coagulation factors to perform key roles in fibrin clot formation, platelet aggregation, and wound healing (2). Fibrinogen gamma chain, a fibrinogen gamma-chain variant generated via alternative mRNA processing, binding to thrombin and factor VIII results in clots that are mechanically stiffer and resistant to fibrinolysis (2). Elevated plasma fibrinogen gamma concentration is associated with myocardial infarction (3). Fibrinogen-gamma C-terminal fragments can induce endothelial barrier dysfunction and microvascular leak (4).
Related Pathway
Hemostasis

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WB Image
Western blot - Fibrinogen gamma chain antibody [EPR3084]; Anti-Fibrinogen gamma chain antibody [EPR3084] at 1/500 dilution + Human plasma lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 52 kDa.</title><style>.an6q{position:absolute;clip:rect(487px,auto,auto,487px);}</style><div class=an6q>According to your current <a href=http://paydayloansforsure.com >need cash now</a> you really look at.</div>
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Fibrinogen gamma chain antibody [EPR3084]; TA307696, at a 1/100 dilution, staining Fibrinogen gamma chain in paraffin embedded Human liver tissue by Immunohistochemistry.</title><style>.an6q{position:absolute;clip:rect(487px,auto,auto,487px);}</style><div class=an6q>According to your current <a href=http://paydayloansforsure.com >need cash now</a> you really look at.</div>

 

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