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Anti-FGG Antibody EPR3084
|A synthetic peptide corresponding to residues in human Fibrinogen gamma chain was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||IHC: 1:100 - 250, WB: 1:500 - 1,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A|
|fibrinogen, gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain|
|Fibrinogen is comprised of two sets of three polypeptide chains termed alpha, beta and gamma that are joined by disulfide bridging within the N-terminal E domain (1). Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen binds through its gamma chain to cell surface receptors, growth factors, and coagulation factors to perform key roles in fibrin clot formation, platelet aggregation, and wound healing (2). Fibrinogen gamma chain, a fibrinogen gamma-chain variant generated via alternative mRNA processing, binding to thrombin and factor VIII results in clots that are mechanically stiffer and resistant to fibrinolysis (2). Elevated plasma fibrinogen gamma concentration is associated with myocardial infarction (3). Fibrinogen-gamma C-terminal fragments can induce endothelial barrier dysfunction and microvascular leak (4). |
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Western blot - Fibrinogen gamma chain antibody [EPR3084]; Anti-Fibrinogen gamma chain antibody [EPR3084] at 1/500 dilution + Human plasma lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 52 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Fibrinogen gamma chain antibody [EPR3084]; ab92481, at a 1/100 dilution, staining Fibrinogen gamma chain in paraffin embedded Human liver tissue by Immunohistochemistry.