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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody EPR354(3)

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307692 Rabbit monoclonal antibody against p53 Acetyl (K305)(clone EPR354(3)) 100ul $325 2 Weeks
LC400186 TP53 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenA synthetic acetylated peptide corresponding to residues surrounding Lysine 305 of human p53 was used as an immunogen. The antibody only detects p53 acetylated on Lysine 305.
Clone NameEPR354(3) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 44 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Entrez Gene 7157 Human
Entrez Gene 24842 Rat
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. It is acetylated at lysine 305, which is a p300 acetyltransferase-mediated acetylation site (4).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome MAPK signaling pathwayCell cyclep53 signaling pathwayApoptosisWnt signaling pathwayNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - p53 (acetyl K305) antibody [EPR354(3)]; All lanes : Anti-p53 (acetyl K305) antibody [EPR354(3)] at 1/1000 dilution.Lane 1 : HepG2 cell lysate, untreated.Lane 2 : HepG2 cell lysate, treated with etoposide and TSA.Lysates/proteins at 10 ug per lane.Predicted band size : 44 kDa.
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