T-cell surface glycoprotein CD4 (CD4) is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is reported that CD4 regulates T-cell activation and induces the aggregation of lipid rafts. CD4 associates with LCK, binds to HIV-1 gp120 and to P4HB/PDI, and upon HIV-1 binding to the cell membrane, it is part of the P4HB/PDI-CD4-CXCR4-gp120 complex. Cell surface expression of CD4 is down-modulated by HIV-1 Envelope polyprotein gp160, which interacts with and sequesters CD4 in the endoplasmic reticulum (1).
Hematopoietic cell lineage
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