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Home Antibody All anti-CD4 antibodies

Anti-CD4 Antibody EPR3942

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307683
  • Rabbit monoclonal antibody against CD4(clone EPR3942)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400209) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for CD4 (NM_000616)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human CD4 was used as an immunogen.
Clone NameEPR3942 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsICC/IF: 1:50 - 1:100; WB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens CD4 molecule (CD4), transcript variant 1
Alternative NameCD4mut
Database LinkNP_000607
FunctionT-cell surface glycoprotein CD4 (CD4) is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is said to possibly regulate T-cell activation and induce the aggregation of lipid rafts. CD4 associates with LCK, binds to HIV-1 gp120 and to P4HB/PDI, and upon HIV-1 binding to the cell membrane, it is part of the P4HB/PDI-CD4-CXCR4-gp120 complex. The subcellular location of CD4 is in the cell membrane; it is a single-pass type I membrane protein that localizes to lipid rafts. Cell surface expression of CD4 is down-modulated by HIV-1 Envelope polyprotein gp160, which interacts with and sequesters CD4 in the endoplasmic reticulum (1).
Related Pathway
Hematopoietic cell lineage

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CD4 antibody [EPR3942]; All lanes : Anti-CD4 antibody [EPR3942] at 1/1000 dilution.Lane 1 : Human tonsil lysates.Lane 2 : Fetal thymus lysates.Lane 3 : HuT-78 lysates.Lane 4 : Peripheral Blood Mononuclear Cell (PBMC) lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.

 

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