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Anti-AGTR2 Antibody EPR3876


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Type-2 Angiotensin II receptor(clone EPR3876)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400227) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-term of human Type-2 angiotensin II receptor was used as an immunogen.
Clone NameEPR3876 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsIP: 1:10 - 100, WB: 1:1,000 - 10,000,
Predicted MW Explanation 41 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens angiotensin II receptor, type 2 (AGTR2)
Alternative NameAT2; ATGR2; MRX88
Database LinkNP_000677
Entrez Gene 186 Human
Entrez Gene 11609 Mouse
Entrez Gene 24182 Rat
FunctionThe angiotensin II type 2 (AT2) receptor, belonging to the seven transmembrane receptor superfamily, interacts with effector peptide angiotensin II and has demonstrated counterregulatory interactions with angiotensin II type 1 (AT1) receptor in both the cardiovascular and renal systems(1,2). Participation of AT1 and AT2 receptors in regulating blood pressure, cardiovascular growth, fibrosis, and remodeling and renal blood flow, growth, fibrosis, and sodium excretion has been suggested(3). AT2 receptor activation also suppresses renin biosynthesis and release at renal juxtaglomerular cells. (3) Unlike AT1 receptor which is expressed ubiquitously and abundantly in adult tissues, AT2 receptor expression is high in the fetus but low in adult tissues, and its cardiovascular expression increases in response to injury and AT1 receptor blocker therapy(2).
Related PathwayGPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interactionRenin-angiotensin system

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Angiotensin II Type 2 Receptor antibody [EPR3876]; All lanes : Anti-Angiotensin II Type 2 Receptor antibody [EPR3876] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 41 kDa.


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