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Anti-AGTR2 Antibody EPR3876
Also for AGTR2 (NM_000686)
|A synthetic peptide corresponding to residues at the C-term of human Type-2 angiotensin II receptor was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||IP: 1:10 - 100, WB: 1:1,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens angiotensin II receptor, type 2 (AGTR2)|
|AT2; ATGR2; MRX88|
|The angiotensin II type 2 (AT2) receptor, belonging to the seven transmembrane receptor superfamily, interacts with effector peptide angiotensin II and has demonstrated counterregulatory interactions with angiotensin II type 1 (AT1) receptor in both the cardiovascular and renal systems(1,2). Participation of AT1 and AT2 receptors in regulating blood pressure, cardiovascular growth, fibrosis, and remodeling and renal blood flow, growth, fibrosis, and sodium excretion has been suggested(3). AT2 receptor activation also suppresses renin biosynthesis and release at renal juxtaglomerular cells. (3) Unlike AT1 receptor which is expressed ubiquitously and abundantly in adult tissues, AT2 receptor expression is high in the fetus but low in adult tissues, and its cardiovascular expression increases in response to injury and AT1 receptor blocker therapy(2).|
Signaling by GPCR
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Western blot - Angiotensin II Type 2 Receptor antibody [EPR3876]; All lanes : Anti-Angiotensin II Type 2 Receptor antibody [EPR3876] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Fetal liver lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 41 kDa.