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Home Antibody All anti-CHRNB1 antibodies

Anti-CHRNB1 Antibody EPR2068

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307671
  • Rabbit monoclonal antibody against ACHR-beta (clone EPR2068 )
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human ACHR-beta was used as an immunogen.
Clone NameEPR2068 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; FC: 1:50
Predicted MW Explanation 57 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens cholinergic receptor, nicotinic, beta 1 (muscle) (CHRNB1)
Alternative NameACHRB; CHRNB; CMS1D; CMS2A; SCCMS
Database LinkNP_000738
Entrez Gene 1140 Human
Entrez Gene 11443 Mouse
Entrez Gene 24261 Rat
FunctionThe nicotinic acetylcholine receptor controls electrical signaling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. The gate is a constricting hydrophobic girdle at the middle of the lipid bi-layer, formed by weak interactions between neighboring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore (1). The widespread distribution of the beta subunit suggests it may serve as a common subunit in different AChR combinations in various brain regions. Regulation of the expression of beta subunit appears to be relatively unrestrained, with an apparent excess of protein synthesized in the cytoplasm relative to that which ultimately arrives at functional targets in the plasma membrane (2).
Related PathwayIon Channels: Cys-loop ReceptorsTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Nicotinic Acetylcholine Receptor beta antibody [EPR2068]; All lanes : Anti-Nicotinic Acetylcholine Receptor beta antibody [EPR2068] at 1/1000 dilution.Lane 1 : fetal brain lysate.Lane 2 : fetal thymus lysate.Lane 3 : skeletal muscle lysate.Lane 4 : heart lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 57 kDa.

 

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