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Anti-CHRNB1 Antibody EPR2068
Also for CHRNB1 (NM_000747)
|A synthetic peptide corresponding to residues in human ACHR-beta was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:5000; FC: 1:50
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for ICC/IF,IHC-P or IP.
|Homo sapiens cholinergic receptor, nicotinic, beta 1 (muscle) (CHRNB1)|
|ACHRB; CHRNB; CMS1D; CMS2A; SCCMS|
|The nicotinic acetylcholine receptor controls electrical signaling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. The gate is a constricting hydrophobic girdle at the middle of the lipid bi-layer, formed by weak interactions between neighboring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore (1). The widespread distribution of the beta subunit suggests it may serve as a common subunit in different AChR combinations in various brain regions. Regulation of the expression of beta subunit appears to be relatively unrestrained, with an apparent excess of protein synthesized in the cytoplasm relative to that which ultimately arrives at functional targets in the plasma membrane (2). |
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Western blot - Anti-Nicotinic Acetylcholine Receptor beta antibody [EPR2068]; All lanes : Anti-Nicotinic Acetylcholine Receptor beta antibody [EPR2068] at 1/1000 dilution.Lane 1 : fetal brain lysate.Lane 2 : fetal thymus lysate.Lane 3 : skeletal muscle lysate.Lane 4 : heart lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 57 kDa.