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Home Antibody All anti-GAD1 antibodies

Anti-GAD1 Antibody EPR2550

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SKU Description Amount Price Availability*  
TA307666
  • Rabbit monoclonal antibody against GAD1(clone EPR2550)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400290) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human GAD1 was used as an immunogen.
Clone NameEPR2550 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Predicted MW Explanation 67 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens glutamate decarboxylase 1 (brain, 67kDa) (GAD1), transcript variant GAD67
Alternative NameCPSQ1; GAD; SCP
Database LinkNP_000808
Entrez Gene 2571 Human
Entrez Gene 14415 Mouse
Entrez Gene 24379 Rat
FunctionGAD1 is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. GAD1 may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures (1).
Related PathwayDruggable Genome Alanine, aspartate and glutamate metabolismbeta-Alanine metabolismTaurine and hypotaurine metabolismButanoate metabolismMetabolic pathwaysType I diabetes mellitusMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - GAD67 antibody [EPR2550]; All lanes : Anti-GAD67 antibody [EPR2550] at 1/1000 dilution.Lane 1 : Human fetal brain cell lysate.Lane 2 : SH-SY5Y cell lysate.Lane 3 : Human fetal hypothalamus cell lysate.Lane 4 : Jurkat cell lysate.Lane 5 : C6 cell lysate.Lane 6 : Neuro2a cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 67 kDa.

 

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