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Anti-GAD1 Antibody EPR2550
Also for GAD1 (NM_000817)
|A synthetic peptide corresponding to residues in human GAD1 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens glutamate decarboxylase 1 (brain, 67kDa) (GAD1), transcript variant GAD67|
|CPSQ1; GAD; SCP|
|GAD1 is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. GAD1 may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures (1).|
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Western blot - GAD67 antibody [EPR2550]; All lanes : Anti-GAD67 antibody [EPR2550] at 1/1000 dilution.Lane 1 : Human fetal brain cell lysate.Lane 2 : SH-SY5Y cell lysate.Lane 3 : Human fetal hypothalamus cell lysate.Lane 4 : Jurkat cell lysate.Lane 5 : C6 cell lysate.Lane 6 : Neuro2a cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 67 kDa.