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Anti-ITGAX Antibody EPR1346


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against CD11c/ITGAX(clone EPR1346)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424468) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

Immunogen A synthetic peptide corresponding to residues in human CD11c/ITGAX was used as an immunogen.
Clone NameEPR1346 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:250 - 1:500
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), transcript variant 2
Alternative NameCD11C; SLEB6
Database LinkNP_000878
Entrez Gene 3687 Human
FunctionIntegrin alpha-X (CD11c, ITGAX) is an integral transmembrane glycoprotein in the integrin alpha chain family that acts as a receptor for fibrinogen (1). CD11c mediates cell-cell interactions during inflammatory responses (1). It is predominantly expressed in leukocytes such as monocytes and granulocytes, playing a critical role in monocyte adhesion and chemotaxis (1). CD11c is also strongly expressed in hairy cell leukemia, a mature B-cell neoplasm (2). CD11c, a heterodimer of an alpha and beta subunit, associates with beta-2 (ITGB2) to form a complement receptor called inactivated-C3b (iC3b) receptor 4 (CR4) (1, 3). CR4 (CD11c/CD18) plays a critical role in adhesion-mediated phagocytosis of macrophages and neutrophils, aided by its expression by dendritic cells (3).
Related PathwayTransmembraneDruggable Genome Regulation of actin cytoskeleton

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-CD11c antibody [EPR1346]; All lanes : Anti-CD11c antibody [EPR1346] at 1/1000 dilution.Lane 1 : HL60 cell lysate, TPA stimulated.Lane 2 : THP1 cell lysate, TPA stimulated.Lysates/proteins at 10 ug per lane.Predicted band size : 127 kDa.


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