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Home Antibody All anti-AR antibodies

Anti-AR Antibody ER179(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307639
  • Rabbit monoclonal antibody against Androgen Receptor(clone ER179(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC423281) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(6)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the N-terminus of human Androgen Receptor was used as an immunogen.
Clone NameER179(2) IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250; ChIP: Use at an assay dependent concentration
Predicted MW Explanation 99 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens androgen receptor (AR), transcript variant 2
Alternative NameAIS; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM
Database LinkNP_001011645
Entrez Gene 367 Human
FunctionAndrogen receptor (AR) is a member of the steroid receptor superfamily that may require coactivators for proper or maximal transactivation. (1). The androgen receptor (AR) is essential for the growth of prostate cancer cells. It has been reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Data suggest that growth factors and their downstream tyrosine kinases, which are elevated during hormone-ablation therapy, can induce tyrosine phosphorylation of AR and such modification may be important for prostate tumor growth under androgen-depleted conditions (2). Cellular signaling occurs following androgen binding to the AR and translocation to the nucleus. This activated complex associates with androgen-responsive elements contained in the DNA sequence of target genes, affecting the transcriptional activity of these genes. Mutations may result in changes in the function or expression of AR protein, or of growth factors and their receptors under the influence of AR coactivators, and AR amplification could lead to activation of the receptor by reduced levels of androgens (3).
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome Oocyte meiosisPathways in cancerProstate cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Androgen Receptor antibody [ER179(2)]; All lanes : Anti-Androgen Receptor antibody [ER179(2)] at 1/1000 dilution.Lane 1 : T47 D cell lysate.Lane 2 : LnCaP cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 99 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Androgen Receptor antibody [ER179(2)]; TA307639, at 1/250, staining Androgen Receptor in paraffin-embedded Human prostatic adenocarcinoma tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Androgen Receptor antibody [ER179(2)]; TA307639, at 1/250, staining Androgen Receptor in paraffin-embedded Human prostate tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [ER179(2)](TA307639); TA307639 showing positive staining in Normal testis tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [ER179(2)](TA307639); TA307639 showing positive staining in Prostatic carcinoma T3 tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [ER179(2)](TA307639); TA307639 showing positive staining in Breast carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [ER179(2)](TA307639); TA307639 showing negative staining in Normal liver tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Androgen Receptor antibody [ER179(2)]; TA307639, at 1/100, staining Androgen Receptor in LnCaP cells by Immunofluorescence.

 

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