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Home Antibody All anti-AR antibodies

Anti-AR Antibody EPR1535(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307638
  • Rabbit monoclonal antibody against Androgen Receptor(clone EPR1535(2))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC423281) , 20ug
100ul $325 In Stock
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WB(1)
IHC(12)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Androgen Receptor was used as an immunogen.
Clone NameEPR1535(2) IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens androgen receptor (AR), transcript variant 2
Alternative NameAIS; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM
Database LinkNP_001011645
FunctionAndrogen receptor (AR) is a member of the steroid receptor superfamily that may require coactivators for proper or maximal transactivation (1). Cellular signaling occurs following androgen binding to the AR and translocation to the nucleus. This activated complex associates with androgen-responsive elements contained in the DNA sequence of target genes, affecting the transcriptional activity of these genes. Mutations may result in changes in the function or expression of AR protein, or of growth factors and their receptors under the influence of AR coactivators; AR amplification also could lead to activation of the receptor by reduced levels of androgens (2). The androgen receptor (AR) is essential for the growth of prostate cancer cells. It has been reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Such modification may be important for prostate tumor growth under androgen-depleted conditions (3).
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - Anti-Androgen Receptor antibody [EPR1535(2)]; All lanes : Anti-Androgen Receptor antibody [EPR1535(2)] at 1/1000 dilution.Lane 1 : T47-D cell lysate.Lane 2 : LnCaP cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 98 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Androgen Receptor antibody [EPR1535(2)]; Immunohistochemical analysis of paraffin-embedded human prostate tissue labelling Androgen Receptor using TA307638, at1/100 dilution
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Androgen Receptor antibody [EPR1535(2)]; Immunohistochemical analysis of paraffin-embedded human prostatic adenocarcinoma tissue labelling Androgen Receptor using TA307638 at 1/100 dilution
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing positive staining in Breast carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing negative staining in Normal brain tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing negative staining in Normal tonsil tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing positive staining in Endometrial carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing negative staining in Normal breast tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing negative staining in Normal colon tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing negative staining in Ovarian carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing negative staining in Colonic adenocarcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing negative staining in Normal liver tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Androgen Receptor antibody [EPR1535(2)](TA307638); TA307638 showing positive staining in Prostatic carcinoma T3 tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-Androgen Receptor antibody [EPR1535(2)]; Immunofluorescent staining of LnCAP cells labelling Androgen Receptor using TA307638, at 1/100 dilution

 

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