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Anti-FOLH1 Antibody EP3254
Also for FOLH1 (NM_001014986)
|A synthetic peptide corresponding to residues near the C-terminus of human PSMA was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||ICC/IF: 1:100 - 1:250; WB: 1:2000 - 1:5000
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 50% Glycerol, 0.05% BSA|
|Protein A purified
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1), transcript variant 2|
|FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA|
Entrez Gene 2346 Human
|PSMA (Prostate-specific membrane antigen, Glutamate carboxypeptidase 2) is a membrane peptidase expressed in the prostate, central and peripheral nervous system, kidney, and small intestine (1). PSMA has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. It is required in the intestine for the uptake of folate, and in the brain it modulates excitatory neurotransmission through the hydrolysis of the neuropeptide N-acetylaspartylglutamate, thereby releasing glutamate (2). In the central nervous system, it is responsible for the cleavage of N-acetyl- L-aspartyl-L-glutamate yielding free glutamate in the synaptic cleft, and is implicated in various pathologic conditions associated with glutamate excitotoxicity (1). PSMA also has abundant and restricted expression on the surface of prostate carcinomas and the neovasculature of most other solid tumors, making it a target for cancer immunotherapy (3). |
|TransmembraneProteaseDruggable Genome |
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Western blot - PSMA antibody [EP3254]; Anti-PSMA antibody [EP3254] at 1/5000 dilution + LnCap lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 84 kDa.Observed band size : 100 kDa .
Immunocytochemistry/ Immunofluorescence - PSMA antibody [EP3254]; Immunofluorescent staining of PSMA in LNCap cells using TA307634 at 1/100 dilution.