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Anti-DNTT Antibody EPR2975
Also for DNTT (NM_001017520)
|A synthetic peptide corresponding to residues in human TDT was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000; FC: 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens DNA nucleotidylexotransferase (DNTT), transcript variant 2|
Entrez Gene 1791 Human
Entrez Gene 21673 Mouse
Entrez Gene 294051 Rat
|Terminal deoxynucleotidyl transferase (TDT) is a unique DNA polymerase that changes the addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator without template direction (1). TDT contributes to the generation of junctional diversity in antigen receptors of immature lymphocytes, and its expression serves as a developmental marker for the sites of teleost lymphopoiesis (2). TDT is also an oligoclonal marker characterizing several populations of undifferentiated or poorly differentiated blasts that tend to develop towards or along the lymphoid pathway. Together with specific immunological markers, this enzyme is useful to define the particular type of leukemic cells (3). |
| Non-homologous end-joiningHematopoietic cell lineage|
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Western blot - TdT antibody [EPR2975]; All lanes : Anti-TdT antibody [EPR2975] at 1/2000 dilution.Lane 1 : Fetal thymus cell lysate.Lane 2 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 58 kDa.Observed band size : 58 kDa.