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Home Antibody All anti-HSP90AA1 antibodies

Anti-HSP90AA1 Antibody EPR3953


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307632 Rabbit monoclonal antibody against Hsp90 Alpha(clone EPR3953) 100ul $325 In Stock
LC400399 HSP90AA1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for HSP90AA1 (NM_001017963)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Hsp90 Alpha was used as an immunogen.
Clone NameEPR3953 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 85 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1), transcript variant 1
Alternative NameEL52; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
Database LinkNP_001017963
Entrez Gene 3320 Human
Entrez Gene 15519 Mouse
Entrez Gene 299331 Rat
FunctionHsp90 Alpha (Heat shock protein 90 alpha) is a cytosolic homodimeric molecular chaperone that modulates the stability and/or transport of a diverse set of critical cellular regulatory, metabolism, organization, and signaling proteins (1). Hsp90 distinguishes itself from other chaperones by having most of its known substrates as signal transduction proteins; e.g. non activated steroid hormone receptors, several proto-oncogenic tyrosine and serine/threonine kinases, and actin (2). These substrates are brought into complex by a multiprotein hsp90/hsp70-based chaperone machinery to function in protein folding (3). Two isoforms correspond to the major and minor isoform, Hsp90 Alpha and Hsp90 Beta. Hsp90 Beta is expressed constitutively to a high level in most tissues and is generally more abundant than Hsp90 Alpha, whereas Hsp90 Alpha is stress-inducible and overexpressed in many cancer cells (4).
Related PathwayDruggable Genome Antigen processing and presentationNOD-like receptor signaling pathwayProgesterone-mediated oocyte maturationPathways in cancerProstate cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Hsp90 alpha antibody [EPR3953]; All lanes : Anti-Hsp90 alpha antibody [EPR3953] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 85 kDa.Observed band size : 90 kDa .

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp90 alpha antibody [EPR3953]; TA307632, at 1/100, staining Hsp90 alpha in paraffin-embedded Human gastric adenocarcinoma tissue by Immunohistochemistry.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp90 alpha antibody [EPR3953]; TA307632, at 1/100, staining Hsp90 alpha in paraffin-embedded Human kidney tissue by Immunohistochemistry.

IF Image
Immunocytochemistry/ Immunofluorescence - Hsp90 alpha antibody [EPR3953]; TA307632, at 1/100, staining Hsp90 alpha in HeLa cells by Immunofluorescence.


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