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Home Antibody All anti-HSP90AA1 antibodies

Anti-HSP90AA1 Antibody EPNCIR102

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307631
  • Rabbit monoclonal antibody against Hsp90 Alpha(clone EPNCIR102)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400399) , 20ug
100ul 379 In Stock
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WB(1)
IHC(1)
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Also for HSP90AA1 (NM_001017963)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Hsp90 Alpha was used as an immunogen.
Clone NameEPNCIR102 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1), transcript variant 1
Alternative NameEL52; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
Database LinkNP_001017963
FunctionHeat shock protein 90 alpha (Hsp90 alpha) is a cytosolic homodimeric molecular chaperone that modulates the stability and/or transport of a diverse set of critical cellular regulatory, metabolism, organization, and signaling proteins (1). Hsp90 distinguishes itself from other chaperones by having most of its known substrates as signal transduction proteins; e.g. non activated steroid hormone receptors, several proto-oncogenic tyrosine and serine/threonine kinases, and actin (2). These substrates are brought into complex by a multiprotein hsp90/hsp70-based chaperone machinery to function in protein folding (3). Two isoforms correspond to the major and minor isoform, Hsp90 alpha and Hsp90 beta. Hsp90 beta is expressed constitutively to a high level in most tissues and is generally more abundant than Hsp90 alpha, whereas Hsp90 alpha is stress-inducible and overexpressed in many cancer cells (4).
Related Pathway
Cell cycle

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Hsp90 alpha antibody [EPNCIR102]; All lanes : Anti-Hsp90 alpha antibody [EPNCIR102] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : SKBR3 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 85 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp90 alpha antibody [EPNCIR102]; TA307631 at 1/50 dilution staining Hsp90 alpha in Human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue.

 

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