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Home Antibody All anti-HSP90AA1 antibodies

Anti-HSP90AA1 Antibody EPNCIR102

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307631 Rabbit monoclonal antibody against Hsp90 Alpha(clone EPNCIR102) 100ul $379 In Stock
LC400399 HSP90AA1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for HSP90AA1 (NM_001017963)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Hsp90 Alpha was used as an immunogen.
Clone NameEPNCIR102 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
Predicted MW Explanation 85 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1), transcript variant 1
Alternative NameEL52; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
Database LinkNP_001017963
Entrez Gene 3320 Human
Entrez Gene 15519 Mouse
Entrez Gene 299331 Rat
FunctionHeat shock protein 90 alpha (Hsp90 alpha) is a cytosolic homodimeric molecular chaperone that modulates the stability and/or transport of a diverse set of critical cellular regulatory, metabolism, organization, and signaling proteins (1). Hsp90 distinguishes itself from other chaperones by having most of its known substrates as signal transduction proteins; e.g. non activated steroid hormone receptors, several proto-oncogenic tyrosine and serine/threonine kinases, and actin (2). These substrates are brought into complex by a multiprotein hsp90/hsp70-based chaperone machinery to function in protein folding (3). Two isoforms correspond to the major and minor isoform, Hsp90 alpha and Hsp90 beta. Hsp90 beta is expressed constitutively to a high level in most tissues and is generally more abundant than Hsp90 alpha, whereas Hsp90 alpha is stress-inducible and overexpressed in many cancer cells (4).
Related PathwayDruggable Genome Antigen processing and presentationNOD-like receptor signaling pathwayProgesterone-mediated oocyte maturationPathways in cancerProstate cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Hsp90 alpha antibody [EPNCIR102]; All lanes : Anti-Hsp90 alpha antibody [EPNCIR102] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : SKBR3 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 85 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp90 alpha antibody [EPNCIR102]; TA307631 at 1/50 dilution staining Hsp90 alpha in Human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
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