FNTA is the alpha subunit for the heterodimeric enzymes CAAX farnesyltransferase and CAAX geranylgeranyltransferase, which catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (1,2). The alpha subunit is thought to participate in a stable complex with the substrate (3).
TGF Beta Signaling Pathway
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