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Home Antibody All anti-CD74 antibodies

Anti-CD74 Antibody EPR4064

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307623
  • Rabbit monoclonal antibody against CD74(clone EPR4064)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422594) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(7)
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Also for CD74 (NM_001025158)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD74 was used as an immunogen.
Clone NameEPR4064 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 3
Alternative NameDHLAG; HLADG; Ia-GAMMA; II
Database LinkNP_001020329
Entrez Gene 972 Human
FunctionCluster of Differentiation 74 (CD74), also known as HLA class II histocompatibility antigen gamma chain, is a type II transmembrane protein that plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis (1). It then directs the transport of this complex from the endoplasmic reticulum to compartments where class II peptide loading occurs (1). CD74 serves as a cell surface receptor ligand for the macrophage migration inhibitory factor (MIF) cytokine, which binds to the extracellular domain of CD74 (1, 2). Thus, CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade, cell proliferation, and PGE2 production (2). CD74 is also expressed on antigen presenting cells such as B cells (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD74 antibody [EPR4064]; Anti-CD74 antibody [EPR4064] at 1/1000 dilution + Ramos cell lysate at 10 ug.Predicted band size : 34 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD74 antibody [EPR4064]; Immunohistochemical analysis of CD74 in paraffin embedded Human tonsil tissue, using TA307623 at a 1/100 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal brain tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing positive staining in B cell lymphoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal placenta tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing positive staining in Normal spleen tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal heart tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal liver tissue.

 

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