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Home Antibody All anti-CD74 antibodies

Anti-CD74 Antibody EPR4064

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307623
  • Rabbit monoclonal antibody against CD74(clone EPR4064)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC422594) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(7)
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Also for CD74 (NM_001025158)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD74 was used as an immunogen.
Clone NameEPR4064 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 3
Alternative NameDHLAG; HLADG; Ia-GAMMA; II
Database LinkNP_001020329
FunctionCluster of Differentiation 74 (CD74), also known as HLA class II histocompatibility antigen gamma chain, is a type II transmembrane protein that plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis (1). It then directs the transport of this complex from the endoplasmic reticulum to compartments where class II peptide loading occurs (1). CD74 serves as a cell surface receptor ligand for the macrophage migration inhibitory factor (MIF) cytokine, which binds to the extracellular domain of CD74 (1, 2). Thus, CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade, cell proliferation, and PGE2 production (2). CD74 is also expressed on antigen presenting cells such as B cells (3).
Related Pathway

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WB Image
Western blot - CD74 antibody [EPR4064]; Anti-CD74 antibody [EPR4064] at 1/1000 dilution + Ramos cell lysate at 10 µg.Predicted band size : 34 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD74 antibody [EPR4064]; Immunohistochemical analysis of CD74 in paraffin embedded Human tonsil tissue, using TA307623 at a 1/100 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal brain tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing positive staining in B cell lymphoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal placenta tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing positive staining in Normal spleen tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal heart tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4064](TA307623); TA307623 showing negative staining in Normal liver tissue.

 

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