Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 3
Synonyms:
DHLAG; HLADG; Ia-GAMMA; II
Immunogen
A synthetic peptide corresponding to residues in human CD74 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Cluster of Differentiation 74 (CD74), also known as HLA class II histocompatibility antigen gamma chain, is a type II transmembrane protein that plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis (1). It then directs the transport of this complex from the endoplasmic reticulum to compartments where class II peptide loading occurs (1). CD74 serves as a cell surface receptor ligand for the macrophage migration inhibitory factor (MIF) cytokine, which binds to the extracellular domain of CD74 (1, 2). Thus, CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade, cell proliferation, and PGE2 production (2). CD74 is also expressed on antigen presenting cells such as B cells (3).
Related Pathway
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