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Home Antibody All anti-CD74 antibodies

Anti-CD74 Antibody EPR4065

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307622
  • Rabbit monoclonal antibody against CD74(clone EPR4065)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422594) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(4)
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Also for CD74 (NM_001025158)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD74 was used as an immunogen.
Clone NameEPR4065 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC: 1:250 - 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 3
Alternative NameDHLAG; HLADG; Ia-GAMMA; II
Database LinkNP_001020329
Entrez Gene 972 Human
FunctionCluster of Differentiation 74 (CD74), also known as HLA class II histocompatibility antigen gamma chain, is a type II transmembrane protein that plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis (1). It then directs the transport of this complex from the endoplasmic reticulum to compartments where class II peptide loading occurs (1). CD74 serves as a cell surface receptor ligand for the macrophage migration inhibitory factor (MIF) cytokine, which binds to the extracellular domain of CD74 (1, 2). Thus, CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade, cell proliferation, and PGE2 production (2). CD74 is also expressed on antigen presenting cells such as B cells (3).
Related PathwayTransmembraneDruggable Genome Antigen processing and presentation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD74 antibody [EPR4065]; All lanes : Anti-CD74 antibody [EPR4065] at 1/1000 dilution.Lane 1 : Human T-78 cell lysate.Lane 2 : Human Tonsil cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 34 kDa.Observed band size : 31 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD74 antibody [EPR4065]; TA307622, at a dilution of 1/250, staining CD74 in paraffin embedded Human tonsil tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4065](TA307622); TA307622 showing positive staining in B cell lymphoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4065](TA307622); TA307622 showing positive staining in Normal thymus tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CD74 antibody [EPR4065](TA307622); TA307622 showing negative staining in Normal brain tissue.

 

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