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Home Antibody All anti-TYMS antibodies

Anti-TYMS Antibody EPR4545

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307614
  • Rabbit monoclonal antibody against TYMS(clone EPR4545)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC420700) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for TYMS (NM_001071)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to the C-terminus in human TYMS was used as an immunogen.
Clone NameEPR4545 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:100 - 1:250; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens thymidylate synthetase (TYMS)
Alternative NameHST422; TMS; TS
Database LinkNP_001062
FunctionThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. TYMS has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of TYMS varies inversely when cell-growth progresses from late-log to plateau phase.
Related Pathway
Cell cycle

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WB Image
Western blot - Thymidylate Synthase antibody [EPR4545]; All lanes : Anti-Thymidylate Synthase antibody [EPR4545] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HL60 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 µg per lane.Performed under reducing conditions.Predicted band size : 36 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Thymidylate Synthase antibody [EPR4545]; TA307614 at 1/50 dilution, staining Thymidylate Synthase in Human ovary carcinoma Immunohistochemistry, Paraffin-embedded tissue.

 

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