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Anti-TYMS Antibody EPR4545
Also for TYMS (NM_001071)
|A synthetic peptide corresponding to the C-terminus in human TYMS was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:100 - 1:250; FC: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens thymidylate synthetase (TYMS)|
|HST422; TMS; TS|
|Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. TYMS has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of TYMS varies inversely when cell-growth progresses from late-log to plateau phase.|
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Western blot - Thymidylate Synthase antibody [EPR4545]; All lanes : Anti-Thymidylate Synthase antibody [EPR4545] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HL60 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 µg per lane.Performed under reducing conditions.Predicted band size : 36 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Thymidylate Synthase antibody [EPR4545]; TA307614 at 1/50 dilution, staining Thymidylate Synthase in Human ovary carcinoma Immunohistochemistry, Paraffin-embedded tissue.