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Anti-CTNND1 PHOSPHO Antibody EPR2383
Also for CTNND1 (NM_001331)
|A phospho-specific peptide corresponding to residues surrounding threonine 916 of human p120 Catenin was used as an immunogen. The antibody only detects p120 Catenin phosphorylated on threonine 916.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||ICC: 1:100 - 250, IHC: 1:100 - 250, WB: 1:5,000 - 50,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens catenin (cadherin-associated protein), delta 1 (CTNND1), transcript variant 3|
|CAS; CTNND; p120; p120(CAS); p120(CTN); P120CAS; P120CTN|
Entrez Gene 1500 Human
|Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
|Druggable Genome Adherens junctionLeukocyte transendothelial migration|
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Western blot - delta 1 Catenin (phospho T916) antibody [EPR2383]; All lanes : Anti-delta 1 Catenin (phospho T916) antibody [EPR2383] at 1/50000 dilution.Lane 1 : 293T cell lysates, untreated.Lane 2 : 293T cell lysates, treated with calyculin A.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 108 kDa.Observed band size : 108 kDa.Additional bands at : 100 kDa (possible isoform).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - delta 1 Catenin (phospho T916) antibody [EPR2383]; TA307609 at 1/100 dilution staining delta 1 Catenin in human ovarian carcinoma by Immunohistochemistry using paraffin-embedded tissue.