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Anti-INPP4B Antibody EPR3108
Also for INPP4B (NM_001101669)
|A synthetic peptide corresponding to residues at the N-terminus of human INPP4B type II was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000; IHC-P: 1:50; FC: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC/IF or IP.
|Homo sapiens inositol polyphosphate-4-phosphatase, type II, 105kDa (INPP4B), transcript variant 2|
Entrez Gene 8821 Human
Entrez Gene 234515 Mouse
Entrez Gene 116699 Rat
|Inositol polyphosphate 4-phosphatase (INPP4B) is an Mg2+ independent enzyme involved in phosphatidylinositol signaling pathways. INPP4B type II catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate. 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. This process rapidly generates two second messengers phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate in response to extracellular signal (1). INPP4B and its secondary messengers have been linked to cell growth, differentiation, apoptosis, protein trafficking, and cell motility (2). It is suggested that INPP4B type II might be subject to alternative splicing, similar to type I enzyme. However, additional factors and/or processing maybe required for alternative isozymes to be active (3).|
|Druggable Genome Inositol phosphate metabolismMetabolic pathwaysPhosphatidylinositol signaling system|
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Western blot - INPP4B antibody [EPR3108]; All lanes : Anti-INPP4B antibody [EPR3108] at 1/5000 dilution.Lane 1 : MCF7 cell lysate .Lane 2 : Fetal skeletal muscle lysate .Lane 3 : Fetal heart lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 107 kDa.Observed band size : 107 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - INPP4B antibody [EPR3108]; Immunohistochemical analysis of paraffin-embedded muscle tissue using TA307601 at 1/50 dilution.