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Home Antibody All anti-INPP4B antibodies

Anti-INPP4B Antibody EPR3108

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307601
  • Rabbit monoclonal antibody against INP4B(clone EPR3108Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420324) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for INPP4B (NM_001101669)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the N-terminus of human INPP4B type II was used as immunogen.
Clone NameEPR3108 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:5000; IHC-P: 1:50; FC: 1:50
Predicted MW Explanation 107 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF or IP.

Reference Data

Target NameHomo sapiens inositol polyphosphate-4-phosphatase, type II, 105kDa (INPP4B), transcript variant 2
Alternative NameMGC132014
Database LinkNP_001095139
Entrez Gene 8821 Human
Entrez Gene 234515 Mouse
Entrez Gene 116699 Rat
FunctionInositol polyphosphate 4-phosphatase (INPP4B) is an Mg2+ independent enzyme involved in phosphatidylinositol signaling pathways. INPP4B type II catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate. 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. This process rapidly generates two second messengers phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate in response to extracellular signal (1). INPP4B and its secondary messengers have been linked to cell growth, differentiation, apoptosis, protein trafficking, and cell motility (2). It is suggested that INPP4B type II might be subject to alternative splicing, similar to type I enzyme. However, additional factors and/or processing maybe required for alternative isozymes to be active (3).
Related PathwayDruggable Genome Inositol phosphate metabolismMetabolic pathwaysPhosphatidylinositol signaling system

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - INPP4B antibody [EPR3108]; All lanes : Anti-INPP4B antibody [EPR3108] at 1/5000 dilution.Lane 1 : MCF7 cell lysate .Lane 2 : Fetal skeletal muscle lysate .Lane 3 : Fetal heart lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 107 kDa.Observed band size : 107 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - INPP4B antibody [EPR3108]; Immunohistochemical analysis of paraffin-embedded muscle tissue using TA307601 at 1/50 dilution.

 

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