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Home Antibody All anti-MMP2 antibodies

Anti-MMP2 Antibody EPR1184

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307594
  • Rabbit monoclonal antibody against MMP-2 (clone EPR1184 )
100ul 325 3-7 Days
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WB(1)
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Also for MMP2 (NM_001127891)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human MMP-2 was used as an immunogen.
Clone NameEPR1184 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsFC: 1:70, WB: 1:1,000 - 5,000,
Predicted MW Explanation 74 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2), transcript variant 2
Alternative NameCLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
Database LinkNP_001121363
Entrez Gene 4313 Human
Entrez Gene 17390 Mouse
Entrez Gene 81686 Rat
FunctionThe matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumor invasion and tumour spread. MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme (1). MMP2 is regulated differently from other MMPs, suggesting that it may play a unique role in cell-matrix interactions, including cell invasion. The conversion from the 72 kDa progelatinase A to the active 62 kDa species may be a key event in the acquisition of invasive potential (2).
Related PathwayProteaseDruggable Genome Leukocyte transendothelial migrationGnRH signaling pathwayPathways in cancerBladder cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MMP2 antibody [EPR1184]; All lanes : Anti-MMP2 antibody [EPR1184] at 1/1000 dilution.Lane 1 : L6 cell lysate.Lane 2 : Fetal heart lysate.Lane 3 : NIH/3T3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 74 kDa.

 

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