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Anti-DNMT1 Antibody EPR3522


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Dnmt1 (clone EPR3522 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC427274) , 20ug Explanation
100ul $325 In Stock
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Also for DNMT1 (NM_001130823)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-terminus of human Dnmt1 was used as an immunogen.
Clone NameEPR3522 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsFC: 1:50, ICC: 1:50 - 100, IP: 1:20, WB: 1:1,000 - 10,000,
Predicted MW Explanation 183 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1
Database LinkNP_001124295
Entrez Gene 1786 Human
FunctionDnmt1 is one of three families of enzymes (Dnmt1, Dnmt2, Dnmt3 (a and b)) that have a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Abnormal methylation patterns are associated with certain human tumors and developmental abnormalities (1). Dnmt1 is responsible for maintenance of the DNA methylation pattern after DNA replication. Dnmt1 is a large protein and can be subdivided into an N- and a C-terminal part. The C-terminal domain harbours the catalytic center. The N-terminal part of the enzyme comprises several individual domains, and plays a role in intracellular targeting and regulation of the enzyme’s activity. Dnmt1 shows a preference for hemimethylated CG sites and the specificity of Dnmt1 for hemimethylated target sites is a key property for that function (2).
Related PathwayTranscription FactorsDruggable Genome Cysteine and methionine metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Dnmt1 antibody [EPR3522]; All lanes : Anti-Dnmt1 antibody [EPR3522] at 1/1000 dilution.Lane 1 : HuT-78 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 183 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Dnmt1 antibody [EPR3522]; Immunofluorescent staining of HeLa cells using TA307585


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