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Anti-NFATC2 Antibody EPR2973
Also for NFATC2 (NM_001136021)
|A synthetic peptide corresponding to residues in human NFAT1 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1,000 - 5,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (NFATC2), transcript variant 3|
|Nuclear factor of activated T-cells, cytoplasmic 2 (NFAT1) belongs to the NFAT family of transcription factors that are expressed in most immune cell types, and play a central role in the transcription of cytokine genes, such as IL-2, IL-4, IL-5, IL-13, IFN-gamma, TNF-alpha, and GM-CSF. The activity NFAT proteins are regulated by the calcium/calmodulin-dependent phosphatase calcineurin, a target for inhibition by CsA and FK506 (1). NFAT1 is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the NFAT transcription complex. This complex plays a central role in inducing gene transcription during the immune response (2). |
MAPK signaling pathway
Wnt Signaling Pathway
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Western blot - NFAT1 antibody [EPR2973]; All lanes : Anti-NFAT1 antibody [EPR2973] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Ramos cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 100 kDa.Observed band size : 135 kDa .