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Anti-CASP6 Antibody EPR4405
Also for CASP6 (NM_001226)
|A synthetic peptide corresponding to the C-terminus of p18 subunit of human Caspase-6 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for ICC or IHC-P.
|Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha|
|Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves many different intracellular proteins, including nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).|
MAPK signaling pathway
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Western blot - Caspase 6 antibody [EPR4405]; All lanes : Anti-Caspase 6 antibody [EPR4405] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Jurkat + staurosporine cell lysate .Lysates/proteins at 10 µg per lane.Predicted band size : 33 kDa.
Flow Cytometry - Caspase 6 antibody [EPR4405]; ab108335, at 1/10 dilution, staining Caspase 6 in permeabilized Jurkat cells by Flow cytometry (shown in red). Rabbit IgG shown in green (negative).