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Home Antibody All anti-CCNE1 antibodies

Anti-CCNE1 Antibody EPR194

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SKU Description Amount Price Availability*  
TA307556
  • Rabbit monoclonal antibody against Cyclin E1(clone EPR194)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400495) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to the C-terminus of human Cyclin E1 was used as an immunogen.
Clone NameEPR194 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens cyclin E1 (CCNE1)
Alternative NameCCNE
Database LinkNP_001229
Entrez Gene 898 Human
FunctionCyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2. Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase (1). The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication (2) Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells. Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis (4).
Related PathwayStem cell relevant signaling - DSL/Notch pathwayStem cell - PluripotencyTranscription FactorsDruggable Genome Cell cycleOocyte meiosisp53 signaling pathwayPathways in cancerProstate cancerSmall cell lung cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-Cyclin E antibody [EPR194]; All lanes : Anti-Cyclin E antibody [EPR194] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : JAR cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 47 kDa.
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