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Anti-CCNE1 Antibody EPR194
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Also for CCNE1 (NM_001238)
|A synthetic peptide corresponding to the C-terminus of human Cyclin E1 was used as an immunogen.|
||WB: 1:1,000 - 10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens cyclin E1 (CCNE1)|
|Cyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2. Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase (1). The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication (2) Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells. Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis (4).|
TGF Beta Signaling Pathway
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Western blot analysis on (A) HeLa, (B) MCF-7, (C) JAR, and (D) K562 cell lysates using anti-Cyclin E1 RabMAb .