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Home Antibody All anti-FOXO3 antibodies

Anti-FOXO3 Antibody EPR1950


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307540 Rabbit monoclonal antibody against FOXO3a(clone EPR1950) 100ul $325 In Stock
LC400566 FOXO3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for FOXO3 (NM_001455)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-terminus of human FOXO3a was used as an immunogen.
Clone NameEPR1950 IsotypeIgG
Species ReactivityMouse, Rat, Human Concentration0.307mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
Predicted MW Explanation 71 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target Nameforkhead box O3
Alternative NameAF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A
Database LinkNP_001446
Entrez Gene 2309 Human
Entrez Gene 56484 Mouse
Entrez Gene 294515 Rat
FunctionForkhead box O-class (FOXO) transcription factors are mammalian homologue of DAF-16, a known lifespan regulator of Caenorhabditis elegans. FOXO transcription factors, such as FOXO1, FOXO3a, and FOXO4, have been linked to the regulation of cell cycle, apoptosis, DNA repair, oxidative stress, and metabolism (1). FOXO proteins are proposed to be dual regulated by Akt-mediated phosphorylation and Skp2-mediated ubiquitination, which are usually initiated by growth factors and cytokines. FOXO proteins are also activated by stress, which induces gene expression that contributes to cell cycle arrest, implicating FOXO proteins as tumor suppressors (2). Specifically, FOXO3a (FKHR-L1) is a transcriptional activator for apoptosis in the absence of survival factors, such as in neural cell death triggered by oxidative stress. In the presence of survival factors like IGF-1, AKT1/PKB phosphorylates on Thr-32 and Ser-253. FOXO3a is inactivated when phosphorylated by AKT1 on Thr-32 and Ser-253 (3).
Related PathwayTranscription FactorsDruggable Genome Chemokine signaling pathwayNeurotrophin signaling pathwayEndometrial cancerNon-small cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - FOXO3A antibody [EPR1950]; All lanes : Anti-FOXO3A antibody [EPR1950] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : SH-SY5Y cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 71 kDa.

IF Image
Immunocytochemistry/ Immunofluorescence - FOXO3A antibody [EPR1950]; Immunofluorescent staining of HeLa cells using TA307540 at a dilution of 1/50.


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