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Home Antibody All anti-FGF2 antibodies

Anti-FGF2 Antibody EP1735


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307494 Rabbit monoclonal antibody against FGF2 (clone EP1735 ) 100ul $325 In Stock
LC400733 FGF2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FGF2 was used as an immunogen.
Clone NameEP1735 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ELISA Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100; Sandwich ELISA: Use a concentration of 0.5 ug/ml
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens fibroblast growth factor 2 (basic) (FGF2)
Alternative NameBFGF; FGF-2; FGFB; HBGF-2
Database LinkNP_001997
Entrez Gene 2247 Human
FunctionBasic fibroblast growth factor (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary. FGF2 has been implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumor growth (1). It is also an important modulator of cartilage and bone growth and differentiation (2). FGF2 consists of multiple protein isoforms produced by alternative translation from the FGF2 gene. High molecular weight FGF2 isoforms are not secreted from the cell, but are transported to the nucleus where they regulate cell growth or behavior in an intracrine fashion. 18 kDa FGF2 can be secreted to the extracellular medium where it acts as a conventional growth factor by binding to and activation of cell-surface receptors (3, 4). These protein isoforms are localized to different cellular compartments, indicating unique biological activity. FGF2 isoforms in the heart have distinct roles in many pathological circumstances in the heart including cardiac hypertrophy, ischemia-reperfusion injury, and atherosclerosis (4).
Related PathwaySecreted ProteinDruggable Genome MAPK signaling pathwayRegulation of actin cytoskeletonPathways in cancerMelanoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - FGF basic antibody [EP1735]; Anti-FGF basic antibody [EP1735] at 1/1000 dilution + K562 cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 31 kDa.

Sandwich ELISA - FGF basic antibody [EP1735]; Standard Curve for FGF basic (Analyte: ; dilution range 1pg/ml to 1ug/ml using Capture Antibody at 1ug/ml and Detector Antibody at 0.5ug/ml.


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