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Home Antibody All anti-FLII antibodies

Anti-FLII Antibody EPR4201

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307493
  • Rabbit monoclonal antibody against Flightless 1(clone EPR4201)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419581) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Flightless 1 was used as an immunogen.
Clone NameEPR4201 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens flightless I homolog (Drosophila) (FLII), transcript variant 1
Alternative NameFLI; Fli1; FLIL
Database LinkNP_002009
FunctionProtein flightless-1 homolog (Flightless 1) is a member of the gelsolin family of actin-remodeling proteins (1). It interacts with various other proteins such as ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2 (2). The cytoskeletal actin remodeling process in Flightless 1 involves severing filaments, capping filament ends, and nucleating actin assembly (3). It is a nuclear receptor co-activator with the ability to interact with other signal transduction proteins (1). In addition, Flightless 1 is involved in estrogen hormone signaling and early embryonic development (2). Its strongest expression is in skeletal muscle, with high expression in the heart and lung (2). The deletion of the Flightless 1 gene may be a cause of Smith-Magenis syndrome, which is characterized by developmental abnormalities and mental retardation (2).
Related Pathway

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WB Image
Western blot - Flightless I antibody [EPR4201]; All lanes : Anti-Flightless I antibody [EPR4201] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : A549 cell lysate.Lane 3 : A431 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 145 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Flightless I antibody [EPR4201]; TA307493 at 1/100 dilution staining Flightless I in Human skeletal muscle by Immunohistochemistry, Paraffin-embedded tissue
IF Image
Immunocytochemistry/ Immunofluorescence - Flightless I antibody [EPR4201]; TA307493 at 1/100 dilution staining Flightless I in HeLa cells by Immunofluorescence.

 

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