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Home Antibody All anti-FLII antibodies

Anti-FLII Antibody EPR4201


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307493 Rabbit monoclonal antibody against Flightless 1(clone EPR4201) 100ul $325 3-7 Days
LC419581 FLII HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Flightless 1 was used as an immunogen.
Clone NameEPR4201 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 145 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens flightless I actin binding protein (FLII), transcript variant 1
Alternative NameFLI; Fli1; FLIL
Database LinkNP_002009
Entrez Gene 2314 Human
Entrez Gene 14248 Mouse
Entrez Gene 287375 Rat
FunctionProtein flightless-1 homolog (Flightless 1) is a member of the gelsolin family of actin-remodeling proteins (1). It interacts with various other proteins such as ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2 (2). The cytoskeletal actin remodeling process in Flightless 1 involves severing filaments, capping filament ends, and nucleating actin assembly (3). It is a nuclear receptor co-activator with the ability to interact with other signal transduction proteins (1). In addition, Flightless 1 is involved in estrogen hormone signaling and early embryonic development (2). Its strongest expression is in skeletal muscle, with high expression in the heart and lung (2). The deletion of the Flightless 1 gene may be a cause of Smith-Magenis syndrome, which is characterized by developmental abnormalities and mental retardation (2).
Related PathwayES Cell Differentiation/IPSTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


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