Homo sapiens flightless I homolog (Drosophila) (FLII), transcript variant 1
Synonyms:
FLI; Fli1; FLIL
Immunogen
A synthetic peptide corresponding to residues in human Flightless 1 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Protein flightless-1 homolog (Flightless 1) is a member of the gelsolin family of actin-remodeling proteins (1). It interacts with various other proteins such as ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2 (2). The cytoskeletal actin remodeling process in Flightless 1 involves severing filaments, capping filament ends, and nucleating actin assembly (3). It is a nuclear receptor co-activator with the ability to interact with other signal transduction proteins (1). In addition, Flightless 1 is involved in estrogen hormone signaling and early embryonic development (2). Its strongest expression is in skeletal muscle, with high expression in the heart and lung (2). The deletion of the Flightless 1 gene may be a cause of Smith-Magenis syndrome, which is characterized by developmental abnormalities and mental retardation (2).
Related Pathway
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