Protein flightless-1 homolog (Flightless 1) is a member of the gelsolin family of actin-remodeling proteins (1). It interacts with various other proteins such as ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2 (2). The cytoskeletal actin remodeling process in Flightless 1 involves severing filaments, capping filament ends, and nucleating actin assembly (3). It is a nuclear receptor co-activator with the ability to interact with other signal transduction proteins (1). In addition, Flightless 1 is involved in estrogen hormone signaling and early embryonic development (2). Its strongest expression is in skeletal muscle, with high expression in the heart and lung (2). The deletion of the Flightless 1 gene may be a cause of Smith-Magenis syndrome, which is characterized by developmental abnormalities and mental retardation (2).
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.