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Anti-FLII Antibody EPR4201
Also for FLII (NM_002018)
|A synthetic peptide corresponding to residues in human Flightless 1 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt.
|Homo sapiens flightless I homolog (Drosophila) (FLII), transcript variant 1|
|FLI; Fli1; FLIL|
|Protein flightless-1 homolog (Flightless 1) is a member of the gelsolin family of actin-remodeling proteins (1). It interacts with various other proteins such as ACTL6A, NCOA2, CARM1, LRRFIP1 and LRRFIP2 (2). The cytoskeletal actin remodeling process in Flightless 1 involves severing filaments, capping filament ends, and nucleating actin assembly (3). It is a nuclear receptor co-activator with the ability to interact with other signal transduction proteins (1). In addition, Flightless 1 is involved in estrogen hormone signaling and early embryonic development (2). Its strongest expression is in skeletal muscle, with high expression in the heart and lung (2). The deletion of the Flightless 1 gene may be a cause of Smith-Magenis syndrome, which is characterized by developmental abnormalities and mental retardation (2).|
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Western blot - Flightless I antibody [EPR4201]; All lanes : Anti-Flightless I antibody [EPR4201] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : A549 cell lysate.Lane 3 : A431 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 145 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Flightless I antibody [EPR4201]; TA307493 at 1/100 dilution staining Flightless I in Human skeletal muscle by Immunohistochemistry, Paraffin-embedded tissue
Immunocytochemistry/ Immunofluorescence - Flightless I antibody [EPR4201]; TA307493 at 1/100 dilution staining Flightless I in HeLa cells by Immunofluorescence.