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Anti-FNTB Antibody EPR4707


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against FNTB(clone EPR4707)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400742) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-terminus of human FNTB was used as an immunogen.
Clone NameEPR4707 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; FC: 1:100 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens farnesyltransferase, CAAX box, beta (FNTB)
Alternative NameFPTB
Database LinkNP_002019
Entrez Gene 2342 Human
FunctionThe mammalian enzyme protein FNTB is a heterodimeric protein composing of two nonidentical subunits designated alpha and beta, which catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins (1,2). The beta subunit is responsible for peptide-binding (1). Chemical modification and site-directed mutagenesis studies have identified a conserved cysteine residue of protein farnesyltransferase, Cys299, in the beta subunit, as important for catalytic activity and zinc binding, suggesting that the thiolate of this residue may directly coordinate the zinc ion (3).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - FNTB antibody [EPR4707]; All lanes : Anti-FNTB antibody [EPR4707] at 1/10000 dilution.Lane 1 : JAR cell lysate.Lane 2 : A431 cell lysate.Lane 3 : U87-MG cell lysate.Lane 4 : A375 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 49 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FNTB antibody [EPR4707]; Immunohistochemical analysis of paraffin-embedded Human breast tissue using TA307491 at 1/100 dilution.


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