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Anti-GCG Antibody EPR4042
|GLP-1 (7-36, amide) conjugated to KLH was used as an immunogen. This antibody recognizes GLP-1 (active).|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ELISA: Use a concentration of 1 ug/ml; IHC-P: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for ,IP or WB.
|Homo sapiens glucagon (GCG)|
|GLP1; GLP2; GRPP|
|Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2. GLP-1 stimulates glucose-dependent insulin secretion and insulin biosynthesis, inhibits glucagon secretion and gastric emptying, and inhibits food intake. The majority of circulating biologically active GLP-1 is found in GLP-1 (7-36, amide), with lesser amounts of bioactive GLP-1 (7-37) form also detectable (1). GLP-1 is inactivated by N-terminal degradation of the peptide by Dipeptidyl Peptidase-4 (DPP-4)-mediated cleavage at position 2, alanine. Application: ELISA and IHC. Optimal dilutions/concentrations should be determined by the end user.|
Signaling by GPCR
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ELISA - Anti-GLP1 antibody [EPR4042]; ELISA: Glucagon-like Peptide (GLP-1) with various concentrations was coated into 96-wells. 1 ug/ml of anti-Glucagon-Like Peptide 1 (GLP-1, 7-36,amide) rabbit monoclonal antibody or the antibody from Vendor X was added. HRP conjugated goat anti-rabbit IgG antibody was used to develop the color.
ELISA - Anti-GLP1 antibody [EPR4042]; ELISA: 1 ug/ml of GLP-1 was coated into 96-wells. Anti-Glucagon-Like Peptide 1 (GLP-1) rabbit monoclonal antibody or the antibody from Vendor X with various concentrations was added. HRP conjugated goat anti-rabbit IgG antibody was used to develop the color.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GLP1 antibody [EPR4042]; TA307489 at 1/100 dilution staining GLP1 in paraffin- embedded Human Pancreas tissue by Immunohistochemistry.