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Home Antibody All anti-GCG antibodies

Anti-GCG Antibody EPR4043

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307488
  • Rabbit monoclonal antibody against Glucagon-Like Peptide 1 (GLP-1)(clone EPR4043)
100ul 325 3-7 Days
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IHC(7)
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Also for GCG (NM_002054)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Glucagon-Like Peptide 1 (GLP-1) was used as an immunogen.
Clone NameEPR4043 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC Suggested DilutionsIHC-P: 1:250 - 1:500
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IP or WB.

Reference Data

Target NameHomo sapiens glucagon (GCG)
Alternative NameGLP1; GLP2; GRPP
Database LinkNP_002045
FunctionGlucagon-like peptide 1 (GLP-1) is a gut hormone resulting from the proteolytic processing of preproglucagon (1). As a potent stimulator of glucose-dependent insulin release, it plays important roles in gastric motility and the suppression of plasma glucagon levels (2). GLP-1 increases islet mass through the stimulation of islet neogenesis and pancreatic beta cell proliferation (2). It also inhibits beta cell apoptosis (2). GLP-1 is secreted from intestinal L cells throughout the gastrointestinal tract and induced in response to nutrient ingestion (2). These physiological functions make GLP-1 a therapeutic target for type 2 diabetes, especially in the treatment of severe hypoglycemia in insulin-dependent diabetics (2).
Related Pathway
Signaling by GPCR

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* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLP1 antibody [EPR4043]; Immunohistochemical analysis of paraffin-embedded Human pancreas tissue labelling GLP1 with TA307488 at 1/250 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-GLP1 antibody [EPR4043](TA307488); TA307488 showing negative staining in Normal colon tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-GLP1 antibody [EPR4043](TA307488); TA307488 showing negative staining in Normal liver tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-GLP1 antibody [EPR4043](TA307488); TA307488 showing positive staining in Pancreas tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-GLP1 antibody [EPR4043](TA307488); TA307488 showing negative staining in Normal tonsil tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-GLP1 antibody [EPR4043](TA307488); TA307488 showing negative staining in Normal breast tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-GLP1 antibody [EPR4043](TA307488); TA307488 showing negative staining in Normal kidney tissue.

 

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