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Home Antibody All anti-HMGB1 antibodies

Anti-HMGB1 Antibody EPR3506

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SKU Description Amount Price Availability*  
TA307477
  • Rabbit monoclonal antibody against HMGB1 (clone EPR3506 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400775) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for HMGB1 (NM_002128)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human HMGB1 was used as an immunogen.
Clone NameEPR3506 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsFC: 1:100, IHC: 1:100 - 250, WB: 1:1000 - 2000,
Predicted MW Explanation 25 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens high mobility group box 1 (HMGB1)
Alternative NameHMG1; HMG3; SBP-1
Database LinkNP_002119
Entrez Gene 3146 Human
Entrez Gene 15289 Mouse
Entrez Gene 25459 Rat
FunctionHigh-mobility group box 1 protein (HMGB1) is a nuclear DNA-binding protein, which also functions as a pleiotropic cytokine, implicated in the pathology of several different immune-mediated diseases (1). As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription. Recent studies identified extracellular HMGB1 as a potent macrophage-activating factor, signaling via the receptor for advanced glycation end-products to induce inflammatory responses. HMGB1 mediates endotoxin lethality, acute lung injury, arthritis induction, activation of macrophages, smooth muscle cell chemotaxis, and epithelial cell barrier dysfunction (2).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - HMGB1 antibody [EPR3506]; All lanes : Anti-HMGB1 antibody [EPR3506] at 1/1000 dilution.Lane 1 : SKBR3 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Molt4 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 25 kDa.Observed band size : 25 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HMGB1 antibody [EPR3506]; TA307477 at 1/100 dilution staining HMGB1 in Human Liver by Immunohistochemistry, Paraffin-embedded tissue. The use of an HRP/AP polymerized antibody is recommended for a secondary antibody.

 

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